The public discussion of the doctoral student (Waleed Khalid Ahmed) of the Department of Chemistry - College of Science - University of Anbar took place on Monday 11/28/2022 in the hall of the College of Computer for his thesis tagged:

((Association of Vitamin D and its receptor polymorphisms with metabolic parameters in polycystic ovary syndrome and some Immuno parameter))

This study summaries to compare vitamin D concentrations in Iraqi women to normal healthy control groups complicated by PCOS, as well as two single nucleotide polymorphisms (SNP A/G rs 1544410 and SNP C/T rs 10735810) in vitamin D receptor (VDR) to PCOS susceptibility in Iraqi women. The goal of this study is to investigate the relationship between VDR and serum levels of 25-hydroxy vit. D, as well as biochemical parameters (BMI, WHR, WC, PRL, LH, FSH, LH/FSH, Testo, E2, AMH, T3, T4, TSH, Insulin Resistance, IL-6, and lipid profile). Both groups had decreased mean serum vitamin D concentrations: PCOS was (14.54.6 ng/ml) and the healthy group has been (40.718) ng/ml), and there were highly significant differences between these groups. There were also significant differences in BMI, WHR, WC, PRL, LH, FSH, LH/FSH, Testo, E2, AMH HOMA-IR, and lipid profile except for high-density lipoprotein cholesterol. There were no significant differences in T3, T4, or TSH concentrations.In PCOS, vitamin D was found to have a significant negative relationship with HOMA-IR ( P ≤ 0.01). The study indicates a correlation between body mass index and PCOS (p < 0.001) . in addition showed between  IL-6 , LH , FSH , LH/FSH , Testo , AMH , TC.,TG., LDL, and VLDL.Polymorphisms in the vitamin D receptor FokI rs (10735810) and BsmI rs (1544410) were not linked to PCOS in Iraqi patients. PCOS preventive genotypes were found to be homozygous CC and homozygous GG (OR <1), whereas PCOS risk genotypes were found to be CT,TT, and GA (OR ≥1). The alleles C and G are preventive alleles (preventive factors), whereas the alleles T and A are etiological alleles (etiological factors).